MPPL Lecture – Chapin Korosec (York University)

Date: Tue. April 8th, 2025, 11:30 am-12:30 pm
Location: Rockefeller 221 (Foldy Room)
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MPPL Lecture #2 (Tuesday, April 18, 11:30am, Rockefeller 221)

Machine learning and dynamical systems modelling of the human immune response to antigenic perturbations

Abstract: Following a vaccine inoculation or disease exposure an immune response develops in time, where the description of its time evolution poses an interesting problem in dynamical systems. The principal goal of theoretical immunology is to construct models capable of describing long term immunological trends from the properties and interactions of its elementary components. In this talk I will give a brief description of the human immune system and introduce a simplified version of its elementary components. I will then discuss our mathematical and machine learning contributions to the field. I will focus on mechanistic modelling work describing vaccine-generated SARS-CoV-2 immunity and applications of our work towards understanding vaccination responses in people living with HIV. Finally, I will discuss our machine learning public health approach, which we find capable of predicting immune response outcomes from repeated-dose immunological data.

[CHAPIN KOROSEC, PhD, York University, Toronto, Canada, has been named the winner of this year’s MICHELSON POSTDOCTORAL PRIZE, and will spend one week in residence during the week of April 7, 2025, on the Case Western Reserve University campus. This year marks the 26th annual MICHELSON POSTDOCTORAL PRIZE LECTURESHIP, awarded each year to a junior scholar active in any field of physics. As part of his residency, Dr. Korosec will deliver two (2) technical lectures and a colloquium.  The lectureship also carries an honorarium of $3,000 plus travel expenses.]