Dark matter annihilation in Galactic substructure will produce diffuse gamma-ray emission of remarkably constant intensity across the sky, making it difficult to disentangle this Galactic dark matter signal from the extragalactic gamma-ray background. Recent studies have considered the angular power spectrum of the diffuse emission from various extragalactic source classes and from Galactic dark matter. I’ll discuss these results and show how the energy dependence of anisotropies in the total measured diffuse emission could be used to confidently identify a signal from dark matter in Fermi data. Finally, I’ll present new results demonstrating that anisotropy analysis could significantly extend the sensitivity of current indirect dark matter searches.